Research on Mechanisms of Chinese Medicines in Prevention and Treatment of Postoperative Adhesion / 中国结合医学杂志

Postoperative adhesion (PA) is currently one of the most unpleasant complications following surgical procedures. Researchers have developed several new strategies to alleviate the formation of PA to a great extent, but so far, no single measure or treatment can meet the expectations and requirements of clinical patients needing complete PA prevention. Chinese medicine (CM) has been widely used for thousands of years based on its remarkable efficacy and indispensable advantages CM treatments are gradually being accepted by modern medicine. Therefore, this review summarizes the formating process of PA and the efficacy and action mechanism of CM treatments, including their pharmacological effects, therapeutic mechanisms and advantages in PA prevention. We aim to improve the understanding of clinicians and researchers on CM prevention in the development of PA and promote the in-depth development and industrialization process of related drugs.

Revolução tecnológica e smartphone: considerações sobre a constituição do sujeito contemporâneo / Revolución tecnológica y smartphone: consideraciones sobre la constitución del sujeto contemporáneo / Technological revolution and smartphone: considerations about the constitution of the contemporary subject

RESUMO. O texto, resultante de estudos teóricos empreendidos à luz da Psicologia Histórico-Cultural entre 2016 e 2020, tem como objetivo recuperar a revolução tecnológica como um recurso para a compreensão da constituição dos sujeitos contemporâneos, partindo da máquina a vapor da Primeira Revolução Industrial, empregada nos meios de produção, até o smartphone, empregado na cotidianidade. O smartphone possui níveis tão altos de compactação, portabilidade e operacionalidade que o tornaram uma das mais avançadas tecnologias da história, revelando o elevado grau de desenvolvimento do psiquismo alcançado pelo gênero humano. Ele, mais do que outras tecnologias digitais de informação e comunicação (TDICs), tem impactado notadamente a constituição dos sujeitos contemporâneos, especialmente suas funções psicológicas cognitivas. Os resultados demonstram que recuperar dialeticamente o percurso histórico das criações tecnológicas é essencial à psicologia, permitindo ampliar o espectro de análise de como os sujeitos se constituem na atualidade. Conclui-se que a revolução microtecnológica deve ser tomada sob um viés crítico e ético, por tudo o que pode impactar nas relações entre os sujeitos e no desenvolvimento dos seus processos psíquicos.

RESUMEN. El texto, resultante de estudios teóricos realizados a la luz de la Psicología Histórico-Cultural entre 2016 y 2020, tiene como objetivo recuperar la revolución tecnológica como un recurso para comprender la constitución de los sujetos contemporáneos, a partir de la máquina de vapor de la Primera Revolución Industrial, empleada en los medios de producción, hasta el smartphone, utilizado en la vida cotidiana. El smartphone tiene niveles tan altos de compacidad, portabilidad y operabilidad que se ha convertido en una de las tecnologías más avanzadas de la historia, revelando el alto grado de desarrollo de la psique alcanzado por la humanidad. Él, más que otras tecnologías digitales de información y comunicación, ha impactado notablemente la constitución de los sujetos contemporáneos, especialmente sus funciones psicológicas cognitivas. Los resultados demuestran que recuperar dialécticamente el camino histórico de las creaciones tecnológicas es esencial para la psicología, lo que permite ampliar el espectro de análisis de cómo se constituyen los sujetos en la actualidad. Concluye que la revolución microtecnológica debe tomarse desde una perspectiva crítica y ética, para todo lo que pueda afectar las relaciones entre los sujetos y el desarrollo de sus procesos psíquicos.

ABSTRACT. The text, resulting from theoretical studies undertaken in the light of Historical-Cultural Psychology between 2016 and 2020, aims to recover the technological revolution as a resource for understanding the constitution of contemporary subjects, starting from the steam engine of the First Industrial Revolution, used in the means of production, even the smartphone, used in everyday life. The smartphone has such high levels of compactness, portability and operability that it has become one of the most advanced technologies in history, revealing the high degree of development of the psyche achieved by mankind. It, more than other digital information and communication technologies, has impacted notably on the constitution of contemporary subjects, especially on their cognitive psychological functions. The results demonstrate that recovering dialectically the historical path of technological creations is essential to Psychology, allowing to expand the spectrum of analysis of how subjects are constituted today. It concludes that the microtechnological revolution must be taken under a critical and ethical bias, due to everything that can impact on the relationships between the subjects and the development of their psychic processes.

Ideologia, confiança institucional e representações sociais de universitários sobre o cenário político brasileiro de 2016-2017 / Ideology, institutional trust, and social representation of university students about the brazilian political scenery from 2016-2017 / Ideología, confianza institucional y representaciones sociales de universitarios sobre el escenario político brasileño de 2016-2017

O objetivo deste estudo foi testar um modelo teórico-explicativo para as representações sociais sobre o cenário sociopolítico brasileiro de 2017, de acordo com as seguintes relações: as representações seriam influenciadas diretamente pela confiança nas instituições, e essa confiança, determinada pelas simpatias ideológicas. Participaram 164 estudantes universitários - cuja idade média era 24 anos - que responderam a escalas intervalares. Realizaram-se modelagens de equações estruturais para testar o modelo teórico proposto. Os resultados indicaram: adequabilidade do modelo; dois grupos de variáveis apresentando relações positivas entre as variáveis do mesmo grupo e negativas na comparação intergrupos. No primeiro grupo constaram as variáveis: ideias-força de esquerda, confiança nos movimentos sociais, avaliação do governo Dilma e avaliação das políticas de esquerda; no segundo: ideias-força de direita, confiança nas instituições de controle, confiança na mídia, avaliação do governo Temer e avaliação das políticas de esquerda. Concluiu-se que a confiança institucional e a simpatia ideológica ancoravam as representações sociais do cenário brasileiro na população universitária estudada.(AU)

The aim of this study was to test an explanatory theoretical model about the social representations about Brazilian social-political scenario in 2017, based on the following relations: representations were directly influenced by the trust in institutions, and this trust, determined by ideological sympathies. A sample of 164 college students - whose average age was 24 years - answered interval scales. We performed structural equation modeling to test the proposed model. The results indicated: the suitability of the model; two groups of variables presenting positive relations in the in-group comparison and negative relations in the comparisons between groups. The first group showed the variables: Leftist ideas-forces, trust in social movements, evaluation of Dilma's administration, and evaluation of Leftist policies; the second: Rightist ideas-forces, trust in control institutions, trust in the media, evaluation of Temer's administration, and evaluation of Leftist policies. In conclusion, the institutional trust and ideological sympathies anchored the social representations of the Brazilian scenery for the studied university population.(AU)

Este estudio tuvo como objetivo probar un modelo teórico explicativo de las representaciones sociales en el escenario sociopolítico brasileño de 2017 según las siguientes relaciones: las representaciones estarían directamente influenciadas por la confianza en las instituciones, y esta confianza, determinada por las simpatías ideológicas. Participaron en este estudio 164 estudiantes universitarios, con edad media de 24 años, quienes respondieron a escalas intervalares. Se llevaron a cabo modelos de ecuaciones estructurales para probar el modelo teórico propuesto. Los resultados indicaron: adecuación del modelo; dos grupos de variables que presentaban relaciones positivas entre las variables del mismo grupo y negativas en la comparación intergrupal. El primer grupo incluía las variables: ideas-fuerza de la izquierda, confianza en los movimientos sociales, evaluación del gobierno de Dilma y evaluación de las políticas de la izquierda; el segundo: ideas-fuerza de la derecha, confianza en las instituciones de control, confianza en los medios de comunicación, evaluación del gobierno Temer y evaluación de las políticas de la izquierda. Se concluyó que la confianza institucional y la simpatía ideológica funcionaron como fundamentos de las representaciones sociales del escenario político brasileño en la población universitaria estudiada.(AU)

Álbum/Relatório das Atividades das Pequenas Irmãs da Divina Providência: registros da assistência médico-social na Região Carbonífera Catarinense, 1955-1957 / Album/Report by the Pequenas Irmãs da Divina Providência: records of social and medical assistance in the coal-producing region of southern Santa Catarina, 1955-1957

Resumo Na primeira metade do século XX, a Região Carbonífera Catarinense passou por um intenso processo de industrialização que impactou diretamente as diferentes formas de vida. Como resultado da exploração do carvão mineral, a região enfrentou uma série de problemas sanitários que dificultavam o próprio processo de acumulação do capital. Diante da incapacidade de o poder público atender às demandas sanitárias, o empresariado local estabeleceu parcerias com congregações religiosas femininas para prestar serviços assistenciais em suas vilas operárias. Como resultado dessa relação, as Pequenas Irmãs da Divina Providência produziram um álbum/relatório, composto por textos, desenhos e fotografias que retratam suas atividades assistenciais, entre 1955 e 1957, em uma das vilas da região.

Abstract During the first half of the twentieth century, the coal-producing region of Santa Catarina state underwent intense industrialization that directly impacted various ways of life; various health problems emerged in the region as a result of coal mining and impeded economic progress. As the government was unable to meet health demands, local businesses established partnerships with female religious orders that provided assistance services in the villages where workers lived. As part of such a partnership, the Pequenas Irmãs da Divina Providência created an album of texts, drawings, and photographs as a report describing their activities from 1955 to 1957 in one such village in the region.

Estudios del despoblamiento rural en Chile: aproximaciones hacia un marco analítico desde la ecología política latinoamericana / Estudos do despovoamento rural no Chile: abordagens para um quadro analítico da ecologia política latino-americana / Studies of rural depopulation in Chile: approaches towards an analytical framework from Latin American political ecology

Resumen El objetivo de este este trabajo fue hacer una revisión documental sobre el despoblamiento rural para ubicar sus principales antecedentes, corrientes y visiones de estudio en Latinoamérica y otros espacios geográficos, con énfasis en Chile para exponer la forma en que la relación entre extractivismo y despoblamiento rural ha sido tratada con la intención de contrastar los resultados con los insumos teóricos de la ecología política latinoamericana y de plantear un análisis integral de este fenómeno. Los resultados muestran que en Chile los factores que han impulsado históricamente el despoblamiento de zonas rurales fueron la dictadura militar, los planes de ordenamiento territorial, industrialización y urbanización, la transformación de la estructura agraria, el cambio climático y el extractivismo. Se constató que los estudios sobre este último factor han omitido la forma en que se produce el despoblamiento, en general en contextos de estructuras de poder desigual y de tensiones territoriales entre distintos modelos de desarrollo y de formas de habitar el espacio. Se propone el campo de la ecología política latinoamericana para abordar los procesos de despoblamiento rural vinculados al extractivismo, cuyos insumos teóricos pueden contribuir a la comprensión más amplia del problema y a la construcción de respuestas con y desde los propios territorios.

Resumo O objetivo deste artigo é realizar uma revisão documental sobre o despovoamento rural para localizar os principais antecedentes, correntes e visões de estudo na América Latina e outros espaços geográficos. A ênfase foi colocada no Chile para expor a forma como tem sido tratada a relação entre extrativismo e despovoamento rural, com a intenção de contrastar os resultados com os aportes teóricos da ecologia política latino-americana e propor uma análise abrangente desse fenômeno. Os resultados mostram que no Chile os fatores que historicamente impulsionam o despovoamento das áreas rurais têm sido a ditadura militar, os planos de ordenamento territorial, a industrialização e a urbanização, a transformação da estrutura agrária, as mudanças climáticas e o extrativismo. Constatou-se que os estudos sobre este último fator têm omitido a forma como ocorre o despovoamento, regularmente em contextos de estruturas de poder desiguais e tensões territoriais entre diferentes modelos de desenvolvimento e formas de habitar o espaço. O campo da ecologia política latino-americana se propõe a abordar os processos de despovoamento rural vinculados ao extrativismo, cujos aportes teóricos podem contribuir para uma compreensão mais ampla do problema e a construção de respostas com e a partir dos próprios territórios.

Abstract The goal was to conduct a documentary review on rural depopulation in order to identify the main antecedents, trends and visions in studies in Latin America and other geographical spaces. Emphasis was placed on Chile to expose the way in which the relationship between extractivism and rural depopulation has been treated, with the intention of contrasting the results with the theoretical inputs of Latin American political ecology and proposing a comprehensive analysis of this phenomenon. Results show that, in Chile, factors historically driving the depopulation of rural areas include the military dictatorship, the territorial ordering plans, industrialization and urbanization, the transformation of the agrarian structure, climate change and extractivism. It was found that studies on this last factor have omitted the way in which depopulation occurs, regularly in contexts of unequal power structures and territorial tensions between different development models and ways of inhabiting space. The field of Latin American political ecology is proposed in order to address the processes of rural depopulation linked to extractivism, since its theoretical inputs can contribute to a broader understanding of the problem and to the construction of responses with and from the territories themselves.

Chinese medicine dispensing granules: history, status quo, and development prospect in "post-pilot era" / 中国中药杂志

Chinese medicine dispensing granules, the result of the efforts to transform Chinese medicinal decoction pieces in China, features portability and ease of storage. Thus, it is destined to be an indispensible dosage form in the modernization drive of Chinese medicine. The Announcement on Ending the Pilot Project of Chinese Medicine Dispensing Granules was released in February 2021 and relevant regulations went into force in November 2021, which marks the a new journey for the development of Chinese medicine dispensing granules and the beginning of the "post-pilot era". However, it faces the challenges in quality and standard. This study reviewed the history of Chinese medicine dispensing granules, analyzed the technical progress, market, and main problems in development, and proposed suggestions and prospects for its development in the "post-pilot era", which is expected to serve as a reference for its industry development and rational use.

Entre os apitos do campo e da fábrica: o futebol à moda Bangu/Rio de Janeiro (1904-1929) / Between the fields of the field and the factory: football in style bangu / Rio de Janeiro (1904-1929 / Entre los campos del campo y la fábrica: fútbol al estilo Bangu / Rio de Janeiro (1904-192

Este trabalho tem como objetivo discutir as peculiaridades do processo de organização do Bangu Athletic Club e o seu progressivo e dependente relacionamento com a Companhia Progresso Industrial do Brasil, entre os anos de 1904 a 1929. Quanto ao recorte temporal (1904-1929), levamos em conta as transformações ocorridas em Bangu ao longo desse período, em 1904 a fundação do Bangu Athletic Club, e em 1929 a fábrica passou por um retalhamento de suas terras, em que, consequentemente, emergiu o bairro Bangu, agora sem ligação direta com a fábrica. Como fontes, foram utilizados revistas e jornais consultados na Hemeroteca Digital da Biblioteca Nacional, além de pedidos de licenciamento e estatutos (AU)

This paper aims to discuss the peculiarities about the organi-zation process of Bangu Athletic Club and its progressive and dependent relationship with Companhia Progresso Industrial do Brasil, between the years 1904 to 1929. Regarding the time frame (1904-1929 ), we take into account the transformations that took place in Bangu throughout that , in 1904, the foundation of the Bangu Athletic club, and 1929, the year in which the factory underwent a shredding of its lands, in which consequently the Bangu neighborhood, now emerged, without direct connection with the factory. As sources were used magazines and news-papers consulted in the Digital Library of the National Library, licensing requests and statutes (AU)

Este artículo tiene como objetivo discutir las peculiaridades del proceso de organización del Bangu Athletic Club y su relación pro-gresiva y dependiente con la Companhia Progresso Industrial do Brasil, entre los años 1904 a 1929. En cuanto al marco temporal (1904-1929 ), tenemos en cuenta las transformaciones que se produjeron en Bangu durante ese período, en 1904, fundación del club Bangu Athletic, y 1929, año en el que la fábrica sufrió un desmembramiento de sus tierras, en el que surgió como consecuencia el barrio de Bangu, ahora sin conexión directa con la fábrica. Como fuentes se utilizaron revistas y periódicos consultados en la Biblioteca Digital de la Biblioteca Nacional, solicitudes de licencias y estatutos (AU).

Biorreactores de un solo uso en la industria biofarmacéutica y su uso en la producción de candidatos vacunales contra SARS- COV-2. Artículo de revisión / Single-use systems bioreactors in the biopharmaceutical industry and its use in SARS-CoV-2 vaccine's candidates production. A review

Los biorreactores de sistemas de un solo uso (SUSs), también conocidos como biorreactores desechables, se han convertido en una parte integral de las instalaciones biotecnológicas de fabricación para bioproductos con un mercado potencial que espera una tasa de crecimiento de casi el 15,5% durante el período pronosticado: 2018 a 2023. Los biorreactores SUSs son más seguros, simples y flexibles al compararlos con sus contrapartes, biorreactores de acero inoxidable, por lo que su uso se está incrementando en la industria biofarmacéutica principalmente en la planificación de vías rápidas de proyectos complejos, incluidos los relacionados con la pandemia de SARS-CoV-2. Así, el uso de SUS se ha convertido en una alternativa eficaz para la producción rápida de candidatos a vacunas. Pero algunas desventajas técnicas y operativas aún obstaculizan su uso en todo el mundo. Esta revisión brinda una visión racional del uso, los tipos, los parámetros operativos y las nuevas aplicaciones de los biorreactores SUSs en la industria biofarmacéutica. Asimismo, también se discuten los parámetros apropiados y las limitaciones de este equipo, enfocándose en su uso para la producción de vacunas contra COVID-19

Single-Use-Systems (SUSs) Bioreactors, also known as disposable bioreactors, have become an integral part of biotechnology manufacturing facilities for bioproducts with a potential market expecting a growth rate of nearly 15.5% over the forecast period: 2018 to 2023. SUSs bioreactors are comparatively safe, simple, and flexible than their stainless-steel bioreactors counterparts thus, their usage is being augmented in the biopharmaceutical industry mainly in planning fast tracks of complex projects, including those related to the SARS-CoV-2 pandemic. Thus, the use of SUSs has become an effective alternative for the rapid production of vaccine candidates. However, some technical and operational disadvantages still hamper their worldwide use. This review gives a rational insight into SUSs bioreactors use, types, operational parameters and new applications in the biopharmaceutical industry. Likewise, the appropriate parameters and limitations of this equipment, focusing on its use for vaccine production against COVID-19 are also discussed

Technology development and instrumentation of a high-throughput and automated microbial microdroplet culture system for microbial evolution and screening / 生物工程学报

Since microdroplets are able to be generated rapidly in large amount and each droplet can be well controlled as an independent micro-cultivator, droplet microfluidic technology can be potentially used in the culture of microorganisms, and provide the microbial culture with high throughput manner. But its application mostly stays in the laboratory-level building and using for scientific research, and the wide use of droplet microfluidics in microbial technology has been limited by the key problems that the operation for microdroplets needs high technical requirements with wide affecting factors and the difficulties in integration of automatic microdroplet instrumentation. In this study, by realizing and integrating the complicated operations of droplet generation, cultivation, detection, splitting, fusion and sorting, we design a miniaturized, fully automated and high-throughput microbial microdroplet culture system (MMC). The MMC can be widely used in microbial growth curve test, laboratory adaptive evolution, single factor and multi-level analysis of microbial culture, metabolite detection and so on, and provide a powerful instrument platform for customized microbial evolution and screening aiming at efficient strain engineering.

An Approach to Technology Development and Current Medical Practice

Abstract Background An approach to technology development and the current medical practice. Objective To consider the many stages of medical-applied technological developments and its main consequences related to the current medical practice and speculate on future developments. Methods Assessment of historical publications and individual and metanalysis of comparative evaluation of old versus new techniques. Results Documentation of progressive improvement in diagnostic skill and therapeutics toward less invasive procedures along the last decades, since the introduction of the scientific medicine. Conclusion Progress has been unequivocally documented albeit an effort to maintain time-proven established previous technique is advised, especially in favor of stimulating a personal patient-physician relationship. (International Journal of Cardiovascular Sciences. 2020; [online].ahead print, PP.0-0)

Saúde, ciência e desenvolvimento: a emergência da leishmaniose tegumentar americana como desafio médico-sanitário no Amazonas / Health, science and development: the emergence of American cutaneous leishmaniasis as a medical and public health challenge in Amazonas state, Brazil

Resumo O artigo faz análise histórica da emergência da leishmaniose tegumentar americana como objeto do conhecimento e desafio médico-sanitário no Amazonas desde a década de 1970. Fornece visão geral dessa época, as medidas sanitárias e os estudos científicos realizados no contexto de implantação dos principais projetos de desenvolvimento regionais executados em nome da política de integração nacional do governo federal. Utiliza como metodologia a análise documental de leis, produção científica, relatórios de pesquisa, boletins epidemiológicos e jornais. Os resultados da pesquisa mostram que a doença surgiu no Amazonas associando o grande problema de saúde com mudanças político-econômicas e alterações socioambientais.

Abstract The history of the emergence of American cutaneous leishmaniasis in the Brazilian state of Amazonas since the 1970s is analyzed as an object of knowledge and a medical and public health challenge. An overview of the period is provided, including the public health measures and scientific studies undertaken in the context of the execution of large-scale regional developments pursued in the name of national integration by the federal government. The methodology uses documental analysis of laws, the scientific literature, research reports, epidemiological bulletins, and newspapers. The results show that American cutaneous leishmaniasis emerged as a major health problem in Amazonas in close association with the political, economic, and socioenvironmental changes seen in the period.

Research on planting area and industrial development strategy of Tibetan medicine / 中国中药杂志

Appropriate producing areas can guarantee the quality of Tibetan medicine, but research on the suitable ecological factors and suitable producing areas of Tibetan medicinal plants is scarce. This paper used the Geographic Information System for Global Medicinal Plants(GMPGIS) to analyze the ecological suitability of Tibetan medicinal plants nationwide. For the first time, the range of ecological factors and main soil types of Tibetan medicinal plants were extracted, such as the average annual temperature-19.4-24.2 ℃, annual average precipitation 17-4 088 mm, annual average sunshine 124.2-171.6 W·m~(-2). The main soil types were black calcareous soil, thin layer soil, chestnut soil and so on. Based on 337 sampling points, the largest ecological similarity area of Tibetan medicine across the country was obtained through ecological similarity analysis. In addition to Tibet and Qinghai provinces and Tibetan Autonomous Prefectures in Sichuan, Gansu, and Yunnan provinces, Jiuquan city and Linxia county in Gansu province, Panzhihua and Ya'an in Sichuan province, and Xinjiang, Inner Mongolia, and Shanxi provinces also had larger suitable cultivation areas. In addition, by analyzing the current situation of Tibetan medicine industry, the research pointed out that there were some problems such as unreasonable development and utilization of resources, lack of standards and norms, weak basic research and imperfect industrial system, and made corresponding countermeasures for sustainable development of resources, formulation of standards and specifications, promotion of medicine through science and technology, expansion of domestic and foreign markets, etc. This study provided the basis for guiding the rational layout of production bases, introduction and breeding of plant Tibetan medicine nationwide, laying the foundation for the scientific and standardized production of high-quality Tibetan medicine, clarifying the development direction of Tibetan medicine industry, and providing ideas for the development strategy of Tibetan medicine and other national medicine industry.

Cultivation strategy on cluster brand of ecological agriculture of Dao-di herbs / 中国中药杂志

The cluster brand is the embodiment of the core competitiveness of an industry. Developing and cultivating cluster brand of ecological agriculture of Dao-di herbs not only helps to optimize the value chain of the Chinese medicinal materials(CMMs) industry cluster, realize the value-added of the CMMs industry cluster, but also enhance the visibility and influence of the industrial cluster, enhance the core competitiveness of the industrial cluster. This has important practical significance for promoting the "orderly" "safe" and "effective" development of the Dao-di herbs. Based on the industry development status of CMMs, this article introduces several concepts related to cluster brands and their relationships, and focuses on the cultivation models and strategies of cluster brand in the CMMs industry. Based on the current status of the development of the CMMs industry, this article introduces several concepts related to cluster brands and their interrelationships. It discusses the cultivation models and strategies of cluster brands in the CMMs industry, industry associations, Chinese medicine companies and individual growers as the support, insists on the ecological cultivation of authentic medicinal materials and the cultivation of cluster brands. Finally, it points out the direction for the high-quality development of the ecological agriculture of CMMs.

Poluição industrial e saúde humana: limitações e potencialidade do uso de bancos de dados públicos em pesquisas empíricas / Industrial pollution and human health: limitations and potential of using public databases in empirical research

O presente trabalho busca explorar o atual cenário da pesquisa brasileira em Ambiente e Sociedade, particularmente no que concerne uma compreensão abrangente dos agravos à saúde. Parte-se de uma perspectiva que compreende os aspectos sociais e ambientais como intrínsecos das condições de saúde. São discutidos aspectos epistemológicos relacionados as pesquisas do campo da Sociologia, com viés ambiental e de saúde pública, considerando contextos empíricos de cidades industriais, neste caso a cidade de Volta Redonda marcada pela presença da Companhia Siderúrgica Nacional. Para tanto, apresenta-se um conjunto de materiais descritivos quanto as produções acadêmicas no campo Ambiente e Sociedade e de bases de dados da área de saúde. As produções acadêmicas selecionadas foram obtidas a partir de levantamentos realizados utilizando os trabalhos apresentados aos Encontros Nacionais da Associação Nacional de Pós-Graduação e Pesquisa em Ambiente e Sociedade, entre 2002 e 2015; e textos publicados na revista Ambiente e Sociedade, de 1999 a 2018. As bases de dados selecionadas, segundo critério de representatividade de casos desfecho ­ óbitos ­ relacionados a agravos do sistema respiratório e disponibilidade de dados sobre presença de material particulado na atmosfera, foram o Sistema de Informação sobre Mortalidade e o Observatório Nacional de Clima e Saúde. (AU)

Robotic Surgery for Rectal Cancer and Cost-Effectiveness

Robotic surgery is considered as one of the advanced treatment modality of minimally invasive surgery for rectal cancer. Robotic rectal surgery has been performed for three decades and its application is gradually expanding along with technology development. It has several technical advantages which include magnified three-dimensional vision, better ergonomics, multiple articulated robotic instruments, and the opportunity to perform remote surgery. The technical benefits of robotic system can help to manipulate more meticulously during technical challenging procedures including total mesorectal excision in narrow pelvis, lateral pelvic node dissection, and intersphincteric resection. It is also reported that robotic rectal surgery have been shown more favorable postoperative functional outcomes. Despite its technical benefits, a majority of studies have been reported that there is rarely clinical or oncologic superiority of robotic surgery for rectal cancer compared to conventional laparoscopic surgery. In addition, robotic rectal surgery showed significantly higher costs than the standard method. Hence, the cost-effectiveness of robotic rectal surgery is still questionable. In order for robotic rectal surgery to further develop in the field of minimally invasive surgery, there should be an obvious cost-effective advantages over laparoscopic surgery, and it is crucial that large-scale prospective randomized trials are required. Positive competition of industries in correlation with technological development may gradually reduce the price of the robotic system, and it will be helpful to increase the cost-effectiveness of robotic rectal surgery.

Review of Worldwide Regulations and Management Systems for Medical Foods

Enteral nutrition (EN) formulas are foods that are used to improve the nutritional status of patients and these foods' safety and quality must be ensured. Therefore, EN formulas in other countries are managed differently from that of general foods. We investigated the direction of development of the relevant laws regulations and guidelines pertaining to EN formulas and we compared these laws regulations and guidelines from different countries, including Korea. The United States and Europe manage EN formulas as foods, but they are managed differently compared to general foods because of separate laws or programs pertaining to EN foods. In addition, the use of the formulas does not necessarily require a prescription, but when used by prescription, then medical insurance covers them. In Japan, there are two types of EN formulas, food and drug, and there are differences for their management and insurance coverage. In the case of Korea, EN formulas are classified as food and drug, and different management and insurance are applied in each case, which inhibits their systematic management and industrial development. Integration of a management system and establishment of a legal foundation is necessary for the systematic management and development of EN formula in Korea.